1022993-24-3Relevant academic research and scientific papers
An efficient synthesis of 4-alkoxy-5,6-dihydro-furo(and -thieno)[2,3-d]pyrimidines using zinc chloride/triethylamine reagent system
Maruoka, Hiroshi,Okabe, Fumi,Yamagata, Kenji
, p. 541 - 545 (2008/09/18)
(Chemical Equation Presented) The one-pot synthesis of 4-alkoxy-5,6- dihydro-furo(and -thieno)[2,3-d]pyrimidines is described. The reactions of 2-benzamido-4,5-dihydro-3-furan(and -3-thiophene)carbonitriles 1a-d and 2a-c with ethanol and/or methanol in the presence of zinc chloride and triethylamine gave the corresponding 4-alkoxy-5,6-dihydro-furo(and -thieno)[2,3-d]pyrimidines 3a-d, 4a-d, 5a-c and 6a-c.
