1023-52-5Relevant academic research and scientific papers
Pyridone modified zinc phthalocyanine as well as preparation method and application thereof
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Paragraph 0043-0045; 0050-0053, (2021/05/19)
The invention discloses pyridone-modified zinc phthalocyanine and a preparation method and application thereof. The pyridone-modified zinc phthalocyanine has the structural formula shown in the specification, novel zinc phthalocyanine is easy and convenie
A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy
Li, Yanqing,Wang, Chongchong,Wei, Shaohua,Zhou, Lin
supporting information, p. 3127 - 3130 (2021/04/02)
A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (1O2) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.
Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst
Godha, Atul K.,Thiruvengadam, Jayaraman,Abhilash, Viswanadhan,Balgi, Prajwal,Narayanareddy,Vignesh, Kumaresan,Gadakh, Amol V.,Sathiyanarayanan,Ganesh, Sambasivam
supporting information, p. 16041 - 16045 (2019/10/28)
An environmentally benign, practically scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst in water. The methodology developed is elaborated into the one-pot synthesis of quinoline derivatives and also applicable to the regioselective N-aralkyl of 2-pyridones.
Specific N-Alkylation of Hydroxypyridines Achieved by a Catalyst- and Base-Free Reaction with Organohalides
Feng, Bin,Li, Yang,Li, Huan,Zhang, Xu,Xie, Huamei,Cao, Hongen,Yu, Lei,Xu, Qing
, p. 6769 - 6775 (2018/05/29)
A specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and
A process for preparing N - alkyl derivatives of green synthesis method
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Paragraph 0053; 0054; 0055, (2017/08/25)
The invention discloses a green synthetic method for preparation of N-alkyl pyridone. According to the method, a hydroxypyridine compound and alcohol undergo selective dehydration N-alkylation under the catalysis of a non-transition metal catalyst, wherein the non-transition metal catalyst is halogenated hydrocarbon; alcohol and the hydroxypyridine compound directly undergo N-selective dehydration under the catalysis of halogenated hydrocarbon so as to obtain an N-alkyl pyridone compound; the usage amount of the halogenated hydrocarbon is 5 to 50 mol%; reaction temperature is 100 to 180 DEG C; reaction time is 6 to 60 hours; and the byproduct is water. The method provided by the invention employs cheap, easily and widely available, stable and low-toxicity alcohol as an alkylating reagent and common halogenated hydrocarbon as the non-transition metal catalyst and directly synthesizes the N-alkyl pyridone compound through highly-selective dehydration N-alkylation without a solvent. The method has low requirements on reaction conditions, a wide application scope and certain research and industrial application prospects.
THERAPEUTIC INHIBITORY COMPOUNDS
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Page/Page column 45, (2015/07/16)
The invention provides compounds of Formula I and Formula II: A-B-C-D-E-F-G-J (I) C-D-E-F-G-J (II) wherein A, B, C, D, E, F, G, and J have any of the values defined in the specification, and salts thereof. The compounds are useful for inhibiting plasma kallikrein, and for treating a disease or condition in an animal where inhibition of plasma kallikrein is indicated.
