1023290-05-2Relevant academic research and scientific papers
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists
Zhang, Xiaohu,Rueter, Jaimie K.,Chen, Yongsheng,Moorjani, Manisha,Lanier, Marion C.,Lin, Emily,Gross, Raymond S.,Tellew, John E.,Williams, John P.,Lechner, Sandra M.,Markison, Stacy,Joswig, Tanya,Malany, Siobhan,Santos, Mark,Castro-Palomino, Julio C.,Crespo, Maria I.,Prat, Maria,Gual, Silvia,Diaz, Jose-Luis,Saunders, John,Slee, Deborah H.
, p. 1778 - 1783 (2008/09/21)
A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A2A antagonists is described. SAR studies led to compound 14 with excellent potency (Ki = 0.4 nM), selectivity (A1/A2A > 100), and efficacy (MED 10 mg/kg po
