1023294-71-4Relevant academic research and scientific papers
NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY
-
Page/Page column 11; 26, (2009/06/27)
This invention relates to novel 4,5-dihydroisoxazoles of formula (I), to their use as estrogen receptor modulators, and to methods of their preparation.
Pd-catalyzed carboetherification ofβ,γ-unsaturated oximes: A novel approach to δ2-lsoxazolines
Jiang, Dahong,Peng, Jinsong,Chen, Yuanwei
supporting information; experimental part, p. 1695 - 1698 (2009/04/12)
A novel route to the synthesis of δ2-isoxazoline derivatives is described. Reaction of β,γ-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted δ2-isoxazollnes in good yields. The use of Xantphos as ligand Is crucial for the transformation. The carboetherification products can be further converted to β-hydroxy ketones in the presence of Fe powder and NH4CI.
