1023294-91-8Relevant academic research and scientific papers
Copper-catalyzed radical oxyallylation of olefins for the construction of alkene-containing isoxazolines
He, Xiaoxue,Qian, Lijie,Dai, Yuyu,Yan, Xinhuan,Li, Xiaoqing,Xu, Xiangsheng
, (2021/05/31)
A radical-mediated approach to alkene oxyallylation using allylic oximes is described. The reaction proceeds under copper-catalytic redox-neutral conditions and tolerates various functional groups. This protocol thus enables the synthesis of structurally valuable isoxazolines and the introduction of a versatile olefin motif in a single step.
Pd-catalyzed carboetherification ofβ,γ-unsaturated oximes: A novel approach to δ2-lsoxazolines
Jiang, Dahong,Peng, Jinsong,Chen, Yuanwei
supporting information; experimental part, p. 1695 - 1698 (2009/04/12)
A novel route to the synthesis of δ2-isoxazoline derivatives is described. Reaction of β,γ-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted δ2-isoxazollnes in good yields. The use of Xantphos as ligand Is crucial for the transformation. The carboetherification products can be further converted to β-hydroxy ketones in the presence of Fe powder and NH4CI.
