1023301-75-8Relevant academic research and scientific papers
Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling
Hayakawa, Ichiro,Ueda, Mitsuru,Yamaura, Masashi,Ikeda, Yoichi,Suzuki, Yuta,Yoshizato, Kensaku,Kigoshi, Hideo
, p. 1859 - 1862 (2008)
Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.
Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues
Ueda, Mitsuru,Yamaura, Masashi,Ikeda, Yoichi,Suzuki, Yuta,Yoshizato, Kensaku,Hayakawa, Ichiro,Kigoshi, Hideo
supporting information; experimental part, p. 3370 - 3377 (2009/09/30)
The total synthesis of haterumalides NA and B, potent cytotoxic marine macrolides, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps. Compared to our first-generation approach for enf-haterumalide NA methy
