102331-29-3Relevant academic research and scientific papers
Avermectin chemistry and action: Ester- and ether-type candidate photoaffinity probes
Tsukamoto, Yoshihisa,Cole, Loretta M.,Casida, John E.
, p. 19 - 26 (2007/10/03)
Avermectin B(1a) (1) is a potent anthelmintic, insecticide, miticide and chloride channel activator on interaction with a specific nerve membrane site analyzed by binding assays with [3H]1. Candidate photoaffinity probes were prepared replacing the dioleandrosyl substituent with potential isosteric esters and ethers approximating the original overall atom length and terminating in a phenyl moiety substituted with azido, iodo or hydroxy. Several of the candidates met the goal of high potency on mouse, housefly and fruit fly brain chloride channels with IC50 values of 7-57 nM in competing for the [3H]1 binding site. (C) 2000 Elsevier Science Ltd.
11-ether derivatives of erythromycins
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, (2008/06/13)
11-ether derivatives of erythromycin, and corresponding 9-(optionally substituted)-amino, 9-imino, and 9-(optionally substituted)-oxime derivatives are novel antibacterially active compounds, and can be prepared by alkylation of the 11-hydroxy group under
