1023339-63-0Relevant academic research and scientific papers
Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates
Roy, Vincent,Kumamoto, Hiroki,Berteina-Raboin, Sabine,Nolan, Steven P.,Topalis, Dimitri,Deville-Bonne, Dominique,Balzarini, Jan,Neyts, Johan,Andrei, Gracelia,Snoeck, Robert,Agrofoglio, Luigi A.
, p. 1399 - 1402 (2007)
With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad functional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group. Copyright Taylor & Francis Group, LLC.
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
Kumamoto, Hiroki,Topalis, Dimitri,Broggi, Julie,Pradère, Ugo,Roy, Vincent,Berteina-Raboin, Sabine,Nolan, Steven P.,Deville-Bonne, Dominique,Andrei, Graciela,Snoeck, Robert,Garin, Daniel,Crance, Jean-Marc,Agrofoglio, Luigi A.
, p. 3517 - 3526 (2008/09/21)
In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.
