1023443-89-1Relevant articles and documents
Chromatography-Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur
Németh, András Gy.,Szabó, Renáta,Domján, Attila,Keser?, Gy?rgy M.,ábrányi-Balogh, Péter
, p. 16 - 27 (2020/12/31)
The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.
Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies
Kanwal,Khan, Majid,Arshia,Khan, Khalid Mohammed,Parveen, Shahnaz,Shaikh, Muniza,Fatima, Narjis,Choudhary, M. Iqbal
, p. 595 - 610 (2018/12/05)
Urease is an enzyme of amidohydrolase family and is responsible for the different pathological conditions in the human body including peptic ulcers, catheter encrustation, kidney stone formation, hepatic coma, encephalopathy, and many others. Therefore, t
