102362-02-7

Basic information

• Product Name: Benzonitrile, 4-acetyl-2-methoxy-
• CAS NO: 102362-02-7
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol File: 102362-02-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-acetyl-2-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-acetyl-2-methoxy-(102362-02-7)
• EPA Substance Registry System: Benzonitrile, 4-acetyl-2-methoxy-(102362-02-7)

Safety Data

• Hazardous Substances Data: 102362-02-7(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 4-acetyl-2-methoxy- is a chemical compound with the molecular formula C10H9NO2. It is also known as 4'-acetyl-2'-methoxybenzonitrile. Benzonitrile, 4-acetyl-2-methoxy- is a derivative of benzonitrile and contains an acetyl group and a methoxy group. It is commonly used in organic synthesis and pharmaceutical research as a starting material for the production of various pharmaceuticals. It possesses potential pharmacological and biological activities, making it a valuable compound for the development of new drugs. Additionally, it has been studied for its potential use as a fluorescent probe in biological imaging. Overall, benzonitrile, 4-acetyl-2-methoxy- is a versatile chemical with various applications in the fields of chemistry and pharmaceuticals.

Upstream product

• 102362-01-6 3-Methoxy-4-cyanobenzoyl chloride 
• 87796-67-6 Lithium bis (trimethylsilyl) malonate 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 330793-38-9 4-bromo-2-methoxybenzonitrile 
• 111-34-2 -butyl vinyl ether 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 66338-51-0 4-ethanoyl-2-methoxyphenyl methanesulfonate 
• 22106-40-7 1-(4-amino-3-methoxyphenyl)ethan-1-one 
• 2486-69-3 3-methoxy-4-aminobenzoic acid 
• 102362-00-5 4-Cyano-3-methoxybenzoic acid 

Downstream Products

• 102362-04-9 4-Acetyl-2-methoxybenzoic acid 
• 130179-76-9 2-(4-Acetyl-2-methoxyphenyl)-1H-imidazo<4,5-c>pyridine 
• 102362-05-0 4-Acetyl-2-methoxy-benzoyl chloride 

Relevant articles and documents

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

A mild and efficient palladium-catalyzed cyanation of aryl mesylates in water or tBuOH/water

Cool and compatible: Aryl mesylates and tosylates underwent palladium-catalyzed cyanation under mild, aqueous conditions at 65-80°C (see scheme). In many cases, water could be used as the reaction medium without a cosolvent, and a variety of substituents R, such as keto, aldehyde, ester, free amine, and nitrile groups, remained intact during the transformation. Cy=cyclohexyl, Ms=methanesulfonyl, Ts=p-toluenesulfonyl.

SUBSTITUENT EFFECTS IN AROMATIC PHOTOCHEMISTRY: UV IRRADIATION OF 3,4-DIMETHOXYBENZONITRILE AND 3,4-DIMETHOXYACETOPHENONE IN THE PRESENCE OF INORGANIC ANIONS

Ultraviolet photolysis of 3,4-dimethoxybenzonitrile (Ia) and 3,4-dimethoxyacetophenone (IIa) in the presence of the hydroxide or cyanide anions leads to nucleophilic displacement of either the para or the meta methoxy substituent.The ratio of isomeric photoproducts is dependent upon the nature of the nucleophile.Photoreactions with the OH(-) anion leads exclusively to the substitution at C-3.On the other hand, both isomers are formed when acetophenone IIa is irradiated in the presence of CN(-), with the C-3/C-4 ratio ranging from 1:2 to 1:6 in dependence on the nucleophile concentration.These difference between the OH(-) and CN(-) anion are related to the results of a fluorescence quenching study which has revealed that only the observed for the quenching of the second excited state of Ia by the cyanide anion.This indicates several distinct quenching modes, in relation to the concentration dependence of regioselectivity.The activating power of -H, -CN, -COCH3, and -NO2 substituents, as measured by relative quantum yields of disappearance for 3,4-dimethoxy-R-substituted benzenes, is 1 : 2.5 : 5 : 580 and 1 : 1.5 : 6 : 1000 in their photoreactions with OH(-) and CN(-) anions, respectively.