1023637-07-1

Downstream Products

• 1023637-10-6 (2'S,3'S)-(2,3,4,6,7-penta-O-benzoyl-L-glycero-α-D-manno-heptopyranosyl)-(1->2)-(7-O-benzyl-6-O-chloroacetyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-α-D-manno-heptopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-(1->4)]-7-O-acetyl-1,6-anhydro-2-O-benzyl-L-glycero-β-D-manno-heptopyranose 
• 1169845-81-1 3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-glucopyranosyl-(1->2)-(2'S,3'S)-7-O-benzyl-6-O-chloroacetyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-α-D-manno-heptopyranosyl-(1->3)-[2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1->4)]-7-O-acetyl-1,6-anhydro-2-O-benzyl-L-glycero-α-D-manno-heptopyranose 
• 1169845-80-0 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-glucopyranosyl-(1->2)-(2'S,3'S)-7-O-benzyl-6-O-chloroacetyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-α-D-manno-heptopyranosyl-(1->3)-[2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1->4)]-7-O-acetyl-1,6-anhydro-2-O-benzyl-L-glycero-α-D-manno-heptopyranose 

Relevant academic research and scientific papers

Synthesis of a common tetrasaccharide motif of Haemophilus influenzae LPS inner core structures

A conserved tetrasaccharide structure, l-glycero-α-d-manno- heptopyranosyl-(1→2)-(6-O-aminoethylphosphono-l-glycero-α-d-manno- heptopyranosyl)-(1→3)-[β-d-glucopyranosyl-(1→4)] -l-glycero-α-d-manno-heptopyranose, from the LPS inner core of Haemophilus influenzae has been synthesised as its ethylamino glycosides to allow later conjugations. Starting from a previously synthesised suitably protected trisaccharide intermediate, the third heptose and subsequently the spacer were introduced using thioglycoside donor chemistry. The phosphoethanolamine was formed employing a Boc-protected phosphoamidite. Final deprotection and conjugation to biotin gave conjugates that will be used to study the specificity of MAbs raised against native LPS structures.