1023710-76-0Relevant academic research and scientific papers
SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS
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Page/Page column 37, (2008/12/07)
The present invention is directed to substituted benzodiazepinones, benzoxazepinones and benzothiazepinones compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are als
3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity
Hoyt, Scott B.,London, Clare,Wyvratt, Matthew J.,Fisher, Michael H.,Cashen, Doreen E.,Felix, John P.,Garcia, Maria L.,Li, Xiaohua,Lyons, Kathryn A.,Euan MacIntyre,Martin, William J.,Priest, Birgit T.,Smith, McHardy M.,Warren, Vivien A.,Williams, Brande S.,Kaczorowski, Gregory J.,Parsons, William H.
, p. 1963 - 1966 (2008/12/21)
A series of 3-amino-1,5-benzodiazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of this series displayed subnanomolar, state-dependent sodium channel block, and was orally efficacious in a mouse model of epilepsy.
