1023710-82-8Relevant academic research and scientific papers
3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity
Hoyt, Scott B.,London, Clare,Wyvratt, Matthew J.,Fisher, Michael H.,Cashen, Doreen E.,Felix, John P.,Garcia, Maria L.,Li, Xiaohua,Lyons, Kathryn A.,Euan MacIntyre,Martin, William J.,Priest, Birgit T.,Smith, McHardy M.,Warren, Vivien A.,Williams, Brande S.,Kaczorowski, Gregory J.,Parsons, William H.
, p. 1963 - 1966 (2008)
A series of 3-amino-1,5-benzodiazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of this series displayed subnanomolar, state-dependent sodium channel block, and was orally efficacious in a mouse model of epilepsy.
