102373-23-9

Upstream product

• 102373-24-0 1-aminocyclohexanecarboxylic acid benzyl ester p-toluenesulfonate 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 100-51-6 benzyl alcohol 
• 468762-35-8 benzyl 1-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 

Downstream Products

• 467443-18-1 1-[3-(4-chloro-phenyl)-ureido]-cyclohexanecarboxylic acid benzyl ester 
• 467443-19-2 1-[3-(3,4-dichloro-phenyl)-ureido]-cyclohexanecarboxylic acid benzyl ester 
• 467443-22-7 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester 
• 219121-39-8 1-(1-tert-butoxycarbonylbut-3-enylamino)cyclohexanecarboxylic acid benzyl ester 
• 944281-07-6 1-[[(2-oxo-1-piperidinyl)carbonyl]amino]cyclohexanecarboxylic acid phenylmethyl ester 
• 944280-23-3 1-[(phenylacetyl)amino]cyclohexanecarboxylic acid phenylmethyl ester 
• 944280-26-6 1-[(4-biphenylcarbonyl)amino]cyclohexanecarboxylic acid phenylmethyl ester 
• 944281-15-6 1-[[(2-oxo-1-imidazolidinyl)carbonyl]amino]cyclohexanecarboxylic acid phenylmethyl ester 
• 944282-15-9 1-[[[4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl] phenyl] carbonyl] amino] cyclohexanecarboxylic acid phenylmethyl ester 
• 236123-25-4 benzyl [(S)-1-[N-tert-butyldimethylsilyl-4-oxo-azetidine-2-carbonyl]amino]cyclohexanecarboxylate 
• 467443-17-0 1-(3-phenyl-ureido)-cyclohexanecarboxylic acid benzyl ester 
• 467443-23-8 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester 

Relevant academic research and scientific papers

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders

The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.

PEPTIDIC COMPOUNDS

The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.