102389-93-5Relevant academic research and scientific papers
Parent and N-substitued azomethine ylides from α-amino acids and formaldehyde. An easy access to 2,5-unsubstituted pyrrolidines. Evidence for oxazolidin-5-ones as direct precursor of these reactive intermediates
Joucla, Marc,Mortier, Jacques
, p. 579 - 583 (2007/10/02)
Formaldehyde reacts with α-amino acids and electron deficient alkenes to produce pyrrolidines.Azomethine ylides involved as intermediates in these reactions have been generated from isolated oxazolidin-5-ones which can be considered as the direct precursors of these ylides.
2,5-Unsubstituted Pyrrolidines from Formaldehyde and Amino Acids through in situ Azomethine-ylide 1,3-Dipolar Cycloaddition to Alkenes
Joucla, Marc,Mortier, Jacques
, p. 1566 - 1567 (2007/10/02)
Formaldehyde and α-amino acids such as sarcosine and glycine react with alkenes to give N-Me and N-H pyrrolidines via in situ generated azomethine-ylides.
