102391-98-0Relevant articles and documents
Comprehensive evaluation of biological effects of pentathiepins on various human cancer cell lines and insights into their mode of action
Wolff, Lisa,Bandaru, Siva Sankar Murthy,Eger, Elias,Lam, Hoai-Nhi,Napierkowski, Martin,Baecker, Daniel,Schulzke, Carola,Bednarski, Patrick J.
, (2021)
Pentathiepins are polysulfur-containing compounds that exert antiproliferative and cytotoxic activity in cancer cells, induce oxidative stress and apoptosis, and inhibit glutathione peroxidase (GPx1). This renders them promising candidates for anticancer
Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms
Mancuso, Francesca,Di Fiore, Anna,De Luca, Laura,Angeli, Andrea,Monti, Simona M.,De Simone, Giuseppina,Supuran, Claudiu T.,Gitto, Rosaria
supporting information, p. 1000 - 1005 (2020/03/23)
We report the synthesis and biochemical evaluation of a series of substituted 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamides (5a-s) developed as inhibitors of druggable carbonic anhydrase (CA) isoforms, as tools for the identification of new therapeu
TETRAZINES FOR HIGH CLICK CONJUGATION YIELD IN VIVO AND HIGH CLICK RELEASE YIELD
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Page/Page column 201, (2019/11/19)
Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield in vivo and high click release yields. In one aspect, the invention relates to kits comprising said tetrazines and a dienophile, preferably a trans-cyclo