1023911-60-5Relevant academic research and scientific papers
Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs
Hanessian, Stephen,Simard, Daniel,Bayrakdarian, Malken,Therrien, Eric,Nilsson, Ingemar,Fjellstroem, Ola
, p. 1972 - 1976 (2008/12/22)
Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives were designed and synthesized having diverse functionality at the P1 and P3 sites. Potent in vitro activity again
