1023953-91-4Relevant academic research and scientific papers
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
Hawryluk, Natalie A.,Merit, Jeffrey E.,Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Swanson, Nadia,Ao, Hong,Maher, Michael P.,Bhattacharya, Anindya,Wang, Qi,Freedman, Jamie M.,Scott, Brian P.,Wickenden, Alan D.,Chaplan, Sandra R.,Breitenbucher, J. Guy
scheme or table, p. 7137 - 7141 (2010/12/25)
Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent antagonists of TRPV1. The tetrahydro-pyrimdoazepines have been identified as having good in vitro and in
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
Shireman, Brock T.,Dvorak, Curt A.,Rudolph, Dale A.,Bonaventure, Pascal,Nepomuceno, Diane,Dvorak, Lisa,Miller, Kirsten L.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 2103 - 2108 (2008/09/20)
The synthesis and SAR for a novel series of 2-alkyl-4-aryl-tetrahydro-pyrido-pyrimidines and 2-alkyl-4-aryl-tetrahydro-pyrimido-azepines is described. Representative compounds were shown to be subtype selective 5-HT2A antagonists. Optimal place
