1023970-53-7Relevant academic research and scientific papers
ALBUMIN BINDING MOLECULES AND USES THEREOF
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Page/Page column 41-42, (2008/12/05)
The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood circulation time and/or the tissue penetration capacity of such agents. Molecules of the invention include compounds represented by Formula (1).
A portable albumin binder from a DNA-encoded chemical library
Dumelin, Christoph E.,Truessel, Sabrina,Buller, Fabian,Trachsel, Eveline,Bootz, Frank,Zhang, Yixin,Mannocci, Luca,Beck, Susanne C.,Drumea-Mirancea, Mihaela,Seeliger, Mathias W.,Baltes, Christof,Mueggler, Thomas,Kranz, Felicitas,Rudin, Markus,Melkko, Samu,Scheuermann, Joerg,Neri, Dario
supporting information; experimental part, p. 3196 - 3201 (2009/02/08)
(Figure Presented) Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).
