1024003-55-1Relevant academic research and scientific papers
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists
Florjancic, Alan S.,Peddi, Sridhar,Perez-Medrano, Arturo,Li, Biqin,Namovic, Marian T.,Grayson, George,Donnelly-Roberts, Diana L.,Jarvis, Michael F.,Carroll, William A.
, p. 2089 - 2092 (2008/12/21)
A novel series of aminotriazole-based P2X7 antagonists was synthesized, and their structure-activity relationships (SAR) were investigated for activity at both human and rat P2X7 receptors. Most compounds showed greater potency at th
