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1024038-90-1

6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1024038-90-1 Structure

  • Basic information

    1. Product Name: 6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide
    2. Synonyms: 6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide
    3. CAS NO:1024038-90-1
    4. Molecular Formula:
    5. Molecular Weight: 295.812
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1024038-90-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide(1024038-90-1)
    11. EPA Substance Registry System: 6-chloro-N-cyclohexyl-2-(propylamino)nicotinamide(1024038-90-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1024038-90-1(Hazardous Substances Data)

1024038-90-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1024038-90-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,4,0,3 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1024038-90:
(9*1)+(8*0)+(7*2)+(6*4)+(5*0)+(4*3)+(3*8)+(2*9)+(1*0)=101
101 % 10 = 1
So 1024038-90-1 is a valid CAS Registry Number.

1024038-90-1Downstream Products

1024038-90-1Relevant articles and documents

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: Discovery of 2-[(3 s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]- 3-piperidyl]acetic acid (AZD4017)

Scott, James S.,Bowker, Suzanne S.,Deschoolmeester, Joanne,Gerhardt, Stefan,Hargreaves, David,Kilgour, Elaine,Lloyd, Adele,Mayers, Rachel M.,McCoull, William,Newcombe, Nicholas J.,Ogg, Derek,Packer, Martin J.,Rees, Amanda,Revill, John,Schofield, Paul,Selmi, Nidhal,Swales, John G.,Whittamore, Paul R. O.

, p. 5951 - 5964 (2012/08/07)

Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. We report here the discovery of a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. Compound 11i (AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development.

CHEMICAL COMPOUNDS

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Page/Page column 78, (2008/12/04)

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.

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