102410-27-5Relevant academic research and scientific papers
Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
Maillard, Ludovic T.,Bertout, Sébastien,Quinonéro, Ophélie,Akalin, Gül?en,Turan-Zitouni, Gülhan,Fulcrand, Pierre,Demirci, Fatih,Martinez, Jean,Masurier, Nicolas
, p. 1803 - 1807 (2013/04/10)
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
Synthesis and biological activity of some 3-methyl/ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles and their 5-bromo/ 5-formyl derivatives
Khazi,Koti,Gadad,Mahajanshetti,Shivakumar,Akki
, p. 393 - 398 (2007/10/03)
Facile reaction of arylacylbromide 1 with 2-amino-4-methylthiazole 2 and its hindered reaction with 2-amino-4-ethoxycarbonylthiazole 3 during the synthesis of 3-methyl/ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles 8/9 are explained on the basis of electron
