1024109-24-7

Usage

Uses

Used in Organic Synthesis:
(2,4,5-trifluorophenyl)hydrazine serves as a valuable building block in organic synthesis, contributing to the creation of a wide range of chemical compounds. Its unique structure, with fluorine atoms enhancing its reactivity and stability, makes it a key component in developing new molecules with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, (2,4,5-trifluorophenyl)hydrazine is utilized as a precursor for the development of various medicinal compounds. Its presence in drug molecules can impart distinct characteristics, such as increased lipophilicity and metabolic stability, which are crucial for drug efficacy and safety.
Used in Agrochemical Industry:
(2,4,5-trifluorophenyl)hydrazine also finds application in the agrochemical field, where it is employed as a starting material for synthesizing pesticides and other crop protection agents. The incorporation of fluorine atoms can lead to improved performance and selectivity of these agrochemicals.
Used in Cancer Treatment Research:
(2,4,5-trifluorophenyl)hydrazine has been investigated for its potential use in the treatment of cancer. Its unique molecular structure allows for the development of compounds that can target specific biological pathways involved in cancer progression, offering new therapeutic options for patients.
However, due to its toxic and potentially hazardous nature, (2,4,5-trifluorophenyl)hydrazine should be handled with caution, adhering to proper safety measures to mitigate risks during its use in research and industrial applications.

Upstream product

• 367-34-0 2,4,5-trifluoroaniline 

Downstream Products

• 1060663-96-8 4-[5-phenyl-1-(2,4,5-trifluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzonitrile 
• 1060663-78-6 3,5-diphenyl-1-(2,4,5-trifluorophenyl)-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship

A series of novel anthranilic diamides derivatives (7a–s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by melting point, 1H NMR, 13C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of 7o against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L?1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L?1 and 20%, 0.1 mg L?1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L?1, superior to chlorantraniliprole (45%, 0.01 mg L?1). The experiments 7o on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, 7o could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of 7o. The density functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations.

Synthesis, insecticidal activities, and structure-activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety

Fluorinated organic compounds represent a growing and important family of commercial chemicals. Introduction of fluorine into active ingredients has become an effective way to develop modern crop protection products. Given the particular properties of fluorine and high efficiency and selectivity of diamide insecticides, we designed and synthesized 27 anthranilic diamides analogues containing fluoro-sustituted phenylpyrazole. A preliminary bioassay indicated that most target compounds exhibited good biological activity against Mythimna separata and Plutella xylostella. Compound IIIf containing a 2,4,6-trifluoro-substituted benzene ring showed 43% insecticidal activity against M. separata at 0.1 mg L-1, while the control chlorantraniliprole was 36%. The activity of IIIe against P. xylostella at 10-5 mg L-1 was 94%, compared with that of the control being 70%. Thus, introduction of fluorine into diamide insecticides was useful for increasing activity. Insect electrophysiology studies showed that the calcium concentration in the nerve cells of third M. separata larvae was elevated by IIIf, which further confirmed that ryanodine receptor (RyR) was its potential target.

Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: A rational design approach for optimizing the contrast ratio of fluorescent probes

A large class of cation-responsive fluorescent sensors utilizes a donor-spacer-acceptor (D-A) molecular framework that can modulate the fluorescence emission intensity through a fast photoinduced intramolecular electron transfer (PET) process. The emissio