102414-27-7Relevant academic research and scientific papers
Antiinflammatory Agents. 4. Syntheses and Biological Evaluation of Potential Prodrugs of 2-Amino-3-benzoylbenzeneacetic Acid and 2-Amino-3-(4-chlorobenzoyl)benzeneacetic Acid
Walsh, David A.,Moran, H. Wayne,Shamblee, Dwight A.,Welstead, William J.,Nolan, Joseph C.,et al.
, p. 2296 - 2304 (2007/10/02)
A series of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid (amfenac) and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid were synthesized and evaluated for their cyclooxygenase inhibiting properties, antiinflammatory potency, and gastrointestinal irritation liability.One compound, 2-amino-3-(4-chlorobenzoyl)benzeneacetamide, possessed a therapeutic index 1 order of magnitude greater than that of indomethacin.
2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor
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, (2008/06/13)
Novel 2-amino-3-benzoylphenethylalcohols are provided having the formula: STR1 wherein; X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl, and Y is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, --S--loweralkyl, STR2 The com
