10242-09-8

Basic information

• Product Name: 5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB010591;5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID;5-METHYL-1-BENZOFURAN-2-CARBOXYLIC ACID;AKOS BB623;5-methyl-1-benzofuran-2-carboxylic acid(SALTDATA: FREE);5-Methyl-2-benzofurancarboxylic acid;2-Benzofurancarboxylic acid, 5-Methyl-
• CAS NO: 10242-09-8
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.17
• Mol File: 10242-09-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 238-240℃
• Boiling Point: 332.1 °C at 760 mmHg
• Flash Point: 154.7 °C
• Appearance: /
• Density: 1.303
• Storage Temp.: 2-8°C
• PKA: 3.16±0.30(Predicted)
• CAS DataBase Reference: 5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(10242-09-8)
• EPA Substance Registry System: 5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(10242-09-8)

Safety Data

• Hazardous Substances Data: 10242-09-8(Hazardous Substances Data)

Usage

General Description

5-Methyl-benzofuran-2-carboxylic acid is a chemical compound with the molecular formula C9H8O3. It is a derivative of benzofuran, a heterocyclic compound containing a benzene ring fused to a furan ring. 5-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also known for its potential biological and pharmacological activities, including anti-inflammatory and antimicrobial properties. Additionally, 5-Methyl-benzofuran-2-carboxylic acid has shown promise in the development of novel drugs for the treatment of various diseases.

Upstream product

• 53715-88-1 ethyl 5-methyl-1-benzofuran-2-carboxylate 
• 88521-73-7 ethyl 2-(2-formyl-4-methylphenoxy)acetate 
• 1159343-21-1 (2-(2,2-dibromovinyl)-4-methylphenol) 
• 13939-06-5 molybdenum hexacarbonyl 
• 1204351-35-8 2-(2-formyl-4-methylphenoxy)acetonitrile 
• 1210226-88-2 C₁₄H₁₆O₃ 
• 13257-19-7 5-chloromethyl-benzofuran-2-carboxylic acid ethyl ester 
• 3199-61-9 ethyl coumarilate 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 92-48-8 6-methylcoumarin 
• 88521-64-6 2-formyl-4-methylphenoxyacetic acid 
• 685-87-0 Diethyl 2-bromomalonate 

Downstream Products

• 312607-99-1 5-methyl-2,3-dihydrobenzofuran-2-carboxylic acid 
• 82788-34-9 methyl 5-methylbenzofuran-2-carboxylate 

Relevant articles and documents

Efficient synthesis of a benzo[b]furan building block

Unexpected difficulty in the conversion of a bromobenzofuran to the corresponding formylbenzofuran led us to develop a new synthesis for 5-formylbenzo[b]furan-2-carbonitrile (1). Copyright

Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C-O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.

Catalytic Asymmetric Dearomatization by Visible-Light-Activated [2+2] Photocycloaddition

A novel method for the catalytic asymmetric dearomatization by visible-light-activated [2+2] photocycloaddition with benzofurans and one example of a benzothiophene is reported, thereby providing chiral tricyclic structures with up to four stereocenters including quaternary stereocenters. The benzofurans and the benzothiophene are functionalized at the 2-position with a chelating N-acylpyrazole moiety which permits the coordination of a visible-light-activatable chiral-at-rhodium Lewis acid catalyst. Computational molecular modeling revealed the origin of the unusual regioselectivity and identified the heteroatom in the heterocycle to be key for the regiocontrol.