10242-10-1

Basic information

• Product Name: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
• Synonyms: ASISCHEM D19360;ASINEX-REAG BAS 12719327;BUTTPARK 40\07-65;5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID;5-Chlorobenzo[b]furan-2-carboxylic acid;5-Chlorobenzofuran-2-carboxylic acid ,97%;5-Chloro-2-benzofurancarboxylic acid;5-Chlorocoumarilic acid
• CAS NO: 10242-10-1
• Molecular Formula: C₉H₅ClO₃
• Molecular Weight: 196.59
• Mol File: 10242-10-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 275°C (subl.)
• Boiling Point: 348.8 °C at 760 mmHg
• Flash Point: 164.7 °C
• Appearance: /
• Density: 1.502
• Vapor Pressure: 1.84E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 2.94±0.30(Predicted)
• CAS DataBase Reference: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(10242-10-1)
• EPA Substance Registry System: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(10242-10-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 10242-10-1(Hazardous Substances Data)

Usage

Chemical Properties

Light red powder

InChI:InChI=1/C9H5ClO3/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4H,(H,11,12)/p-1

Upstream product

• 59962-89-9 ethyl 5-chlorobenzofuran-2-carboxylate 
• 79-11-8 chloroacetic acid 
• 635-93-8 5-chlorosalicyclaldehyde 
• 95186-48-4 4-chloro-2-<2',2'-dibromo ethenyl>-phenol 
• 13939-06-5 molybdenum hexacarbonyl 
• 17798-46-8 (4-chloro-2-formyl-phenoxy)-acetic acid ethyl ester 
• 1927-94-2 3-chlorosalicylaldehyde 
• 685-87-0 Diethyl 2-bromomalonate 

Downstream Products

• 337530-26-4 5-Chloro-N-[(1S)-2-[[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]amino]-2-oxo-1-(pyridin-2-ylmethyl)ethyl]-1-benzofuran-2-carboxamide 

Relevant articles and documents

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Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

A novel series of shikonin-benzo[b]furan derivatives were designed and synthesized as tubulin polymerization inhibitors, and their biological activities were evaluated. Most compounds revealed the comparable anti-proliferation activities against the cancer cell lines to that of shikonin and simultaneously low cytotoxicity to non-cancer cells. Among them, compound 6c displayed powerful anti-cancer activity with the IC50 value of 0.18 μM against HT29 cells, which was significantly better than that of the reference drugs shikonin and CA-4. What's more, 6c could inhibit tubulin polymerization and compete with [3H] colchicine in binding to tubulin. Further biological studies depicted that 6c can induce cell apoptosis and cell mitochondria depolarize, regulate the expression of apoptosis related proteins in HT29 cells. Besides, 6c actuated the HT29 cell cycle arrest at G2/M phase, and influenced the expression of the cell-cycle related protein. Moreover, 6c displayed potent inhibition on cell migration and tube formation that contributes to the antiangiogenesis. These results prompt us to consider 6c as a potential tubulin polymerization inhibitor and is worthy for further study.

INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of ClC-Kb channels

Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of ClC-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hy