102422-37-7

Basic information

• Product Name: N-(1H-imidazol-1-ylcarbonyl)-2-phenethylamine
• Synonyms: N-(1H-imidazol-1-ylcarbonyl)-2-phenethylamine
• CAS NO: 102422-37-7
• Molecular Weight: 215.255
• Mol File: 102422-37-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(1H-imidazol-1-ylcarbonyl)-2-phenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1H-imidazol-1-ylcarbonyl)-2-phenethylamine(102422-37-7)
• EPA Substance Registry System: N-(1H-imidazol-1-ylcarbonyl)-2-phenethylamine(102422-37-7)

Safety Data

• Hazardous Substances Data: 102422-37-7(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 1943-82-4 phenethyl isocyanate 
• 64-04-0 phenethylamine 
• 140-29-4 phenylacetonitrile 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1172614-00-4 (S)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate hydrogensulfate 
• 180272-14-4 (S,R)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 740780-79-4 (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate 
• 242478-37-1 solifenacin 
• 1262506-09-1 solifenacin succinate 
• 380221-69-2 C₃₈H₄₃N₉O₆ 

Relevant articles and documents

Synthesis, characterization, and biological evaluations of substituted phenethylamine-based urea as anticancer and antioxidant agents

Cancer is one of the most important diseases. It is the second leading cause of death worldwide following cardiovascular disease. There is a need to develop new chemotherapeutic agents for the treatment of cancer and it is still a significant task for med

PROCESS FOR THE PREPARATION OF SOLIFENACIN AND SALTS THEREOF

The invention provides a new process for the preparation of solifenacin or a pharmaceutically acceptable acid addition salt thereof, comprising reacting (R)- quinuclidin-3-yl phenethylcarbamate with benzaldehyde in the presence of an acid to obtain a diasteroisomeric mixture (S,R)-((R)-quinuclidin-3-yl) 1 -phenyl-3,4- dihydroisoquinoline-2(1 H)-carboxylate of formula (IV) which can be resolved and the solifenacin or a pharmaceutically acceptable acid addition salt thereof recovered. The invention also provides the new key intermediate (R)-quinuclidin-3-yl phenethylcarbamate involved in the process. Further the invention provides a method for the transformation of (R)-((R)-quinuclidin-3-yl) 1 -phenyl-3,4- dihydroisoquinoline-2(1 H)-carboxylate into a diasteroisomeric mixture (S,R)-((R)- quinuclidin-3-yl) 1 -phenyl-3,4-dihydroisoquinoline-2(1 H)-carboxylate.

The 4-azidobenzyloxycarbonyl function; application as a novel protecting group and potential prodrug modification for amines

A series of 4-azidobenzylcarbamates [4-N3-C6H4-CH2-O-CO-N(H)-C 6H4-X; X = H, Me, MeO, Br, Cl, NO2] have been prepared in good yield, and in high purity, by reaction of 4-azidobenzyl alcohol with the corresponding aryl isocyanate, or by displacement of 4-nitrophenol from 4-azidobenzyl-4-nitrophenylcarbonate by the appropriate amine. The 4-azidobenzylcarbamates were shown to undergo rapid reduction in the presence of dithiothreitol, and the resultant 4-aminobenzylcarbamates underwent immediate cascade degradation to release the target amine. The mild conditions used in this conversion may prove useful in the protection of amines during synthetic procedures or as a possible mode of bioactivation of prodrugs.