102423-06-3

Upstream product

• 102423-04-1 5'-o-monomethoxytrityl-3'-o-t-butyldimethylsilyl-N-allyloxycarbonyldeoxyadenosine 
• 102434-69-5 9-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylamine 

Downstream Products

• 51600-10-3 2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine 
• 102434-69-5 9-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-ylamine 
• 102423-04-1 5'-o-monomethoxytrityl-3'-o-t-butyldimethylsilyl-N-allyloxycarbonyldeoxyadenosine 

Relevant academic research and scientific papers

Electrochemical removal of allylic protecting groups in nucleotide synthesis

Electrochemical, palladium(0)-mediated removal of allylic protecting groups of nucleosides and nucleotides is described. This method required no chromatographic treatment for isolation of the products.

Allyloxycarbonyl Group: A Versatile Blocking Group for Nucleotide Synthesis

Allyloxycarbonyl (AOC) is excellent for the protection of sugar hydroxyls and amino and imide moieties of nucleoside bases.The deblocking is easily performed by brief treatment with a palladium catalyst and a variety of nucleophiles at room temperature.