102448-00-0Relevant academic research and scientific papers
XANTHOHUMOL-BASED COMPOUNDS AND COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME
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Paragraph 0144, (2016/03/01)
Disclosed herein are compounds capable of ameliorating, treating, and preventing metabolic syndrome, or risk factors associated with metabolic syndrome, such as obesity, diabetes, and/or cardiovascular disease. In some embodiments, the compounds can funct
Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro
Tronina, Tomasz,Bartmańska, Agnieszka,Filip-Psurska, Beata,Wietrzyk, Joanna,Pop?oński, Jaros?aw,Huszcza, Ewa
, p. 2001 - 2006 (2013/05/09)
Xanthohumol (1) and xanthohumol D (2) were isolated from spent hops. Isoxanthohumol (3) was obtained from xanthohumol by isomerisation in alkaline solution. Six metabolites were obtained as a result of transformation of xanthohumol (1) by selected fungal cultures. Their structures were established on the basis of their spectral data. One of them: 2″- (2′′′-hydroxyisopropyl)-dihydrofurano-[4″,5″: 3′,4′]-4′,2-dihydroxy-6′-methoxy-α, β-dihydrochalcone (6) has not been previously reported in the literature. The antioxidant properties of hops flavonoids and xanthohumol derivatives were investigated using the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The effects of these compounds on proliferation of MCF-7, PC-3 and HT-29 human cancer cell lines were determined by the SRB assay. With the exception of one metabolite, all tested compounds showed antiproliferative activity against the tested human cancer lines. α,β- Dihydroxanthohumol (4), obtained through the biotransformation of xanthohumol, showed higher antiproliferative activity against MCF-7 human breast carcinoma cell line than cisplatin, a widely used anticancer therapeutic agent, and a comparably high activity against PC-3 human prostate cancer cell line.
