10245-39-3

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 120-72-9 indole 

Downstream Products

• 92311-68-7 N-[3-Chloro-2-(1H-indol-3-yl)-4-oxo-azetidin-1-yl]-benzamide 
• 1313032-31-3 C₈H₄NHCHNNHCOC₆H₅PdCl 
• 1260116-88-8 diethyl [(2-benzoylhydrazino)(1H-indol-3-yl)methyl]phosphonate 

Relevant academic research and scientific papers

Synthesis and anticancer activity study of indolyl hydrazide-hydrazones

A series of N'-((1-(substituted)-1H-indol-3-yl)methylene)hydrazides were synthesized and evaluated for their in vitro antiproliferative activities against various cancer cell lines. Formation of indole hydrazide-hydrazones was accomplished by the reaction of indole 3-carboxaldehyde with aryl/alkyl hydrazides in the presence of acetic acid. Out of synthesized twenty-two compounds, some of the analogs exhibited specificity toward breast (18b, 18d, 18f and 18j) and prostate (18t and 18v) cancer cells. Among the prepared derivatives, compounds 18b, 18d and 18j were most cytotoxic (IC50 = 0.9, 0.4 and 0.8 μM, respectively) against the screened cancer cell lines. Exposure of PC3 cells to either 18d or 18j resulted in increased levels of cleaved PARP1, indicating that indolyl hydrazide-hydrazones induce apoptosis in PC3 cells.

Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: Impact of substitution at the chelating ligand and arene moiety on antiproliferative activity

A convenient method for the synthesis of ruthenium(ii) arene benzhydrazone complexes (1-6) of the general formula [(η6-arene)Ru(L)Cl] (arene-benzene or p-cymene; l-monobasic bidentate substituted indole-3-carboxaldehye benzhydrazone derivatives

Benzoylhydrazones in catalytic hydrophosphorylation

Reactions of benzoylhydrazones derived from heterocyclic and aromatic aldehydes and aliphatic, heterocyclic, and aliphatic-aromatic ketones with diethyl phosphite in the presence of [tetra(tert-butyl)phthalocyanine]aluminum chloride afford α-benzoylhydraz