102451-68-3Relevant academic research and scientific papers
Microwave-accelerated Conjugate Addition of 2-Arylindoles to Substituted β-Nitrostyrenes in the Presence of Ammonium Trifluoroacetate: An Efficient Approach for the Synthesis of a Novel Class of CB1 Cannabinoid Receptor Allosteric Modulators
Kulkarni, Pushkar M.,Ranade, Ameya,Garai, Sumanta,Thakur, Ganesh A.
, p. 2079 - 2084 (2017)
2-Arylindoles, in general, exhibit reduced reactivity towards the conjugate addition to substituted nitrostyrenes, when compared with indoles. We report here an efficient, expeditious, and high-yielding conjugate addition of 2-arylindoles to substituted β
Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Arutiunov, Nikolai A.,Aksenov, Nicolai A.,Aleksandrova, Elena V.,Zhao, Zhenze,Du, Liqin,Kornienko, Alexander,Rubin, Michael
, p. 7123 - 7137 (2019/06/18)
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
Allosteric modulators of CB1 cannabinoid receptors
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Page/Page column 27; 28; 31; 32, (2017/02/24)
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid
ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS
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Paragraph 0083; 0106, (2013/07/19)
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid
