1024583-34-3Relevant academic research and scientific papers
BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
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Page/Page column 67, (2008/12/04)
The invention provides compounds of formula (1 ) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of AIk, AbI, Aurora-A, B-Raf, Bcr-Abl, BRK, BIk, Bmx, c-Kit, c-RAF, cSRC. CSK, FLTl, Fms, Fyn, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα. p38 (p38 MAP kinase, SAPK2α), Src, SIK, Syk, Tie2 and TrkB kinases. FORMULE (I)
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors
Huang, Shenlin,Liu, Zuosheng,Tian, Shin-Shay,Sandberg, Mark,Spalding, Tracy A.,Romeo, Russell,Iskandar, Maya,Wang, Zhiliang,Karanewsky, Donald,He, Yun
, p. 2324 - 2328 (2008/09/20)
A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.
