1024590-31-5Relevant academic research and scientific papers
Synthesis of 3-substituted pyrrolidines
Kurkin,Sumtsova,Yurovskaya
, p. 34 - 40 (2007/10/03)
A method was developed for the synthesis of derivatives of 3-substituted pyrrolidines from activated alkenes by 1,3-dipolar cycloaddition of unstable 2-benzylazomethylide, generated in situ from N-benzyl-N-(methoxymethyl)-N- (trimethylsilyl)amine. A method was developed for the reduction of 4-(3-pyrrolidyl)pyridine, prepared by the above-mentioned method, to the corresponding derivatives of (3-pyrrolidyl)piperidine with high yields under mild conditions.
