1024590-62-2Relevant academic research and scientific papers
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli
Aberg, Veronica,Das, Pralay,Chorell, Erik,Hedenstroem, Mattias,Pinkner, Jerome S.,Hultgren, Scott J.,Almqvist, Fredrik
supporting information; scheme or table, p. 3536 - 3540 (2009/04/05)
Ring-fused 2-pyridones, termed pilicides, are small synthetic compounds that inhibit pilus assembly in uropathogenic Escherichia coli. Their biological activity is clearly dependent upon a carboxylic acid functionality. Here, we present the synthesis and
1H-PYRIDINE- 2 -ONE DERIVATIVES USEFUL IN TREATMENT OF PAI-1 RELATED DISORDERS
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Page/Page column 23, (2008/12/05)
The claimed invention provides 1H-pyridine-2-one derivatives, inhibitors of PAI-1, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I, II and III may be used in the treatment o
