1024596-67-5Relevant academic research and scientific papers
(-)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties
Arthurs, Claire L.,Lingley, Katharine F.,Piacenti, Michela,Stratford, Ian J.,Tatic, Tanja,Whitehead, Roger C.,Wind, Natasha S.
, p. 2410 - 2413 (2008)
Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (-)-quinic acid. The results of bioassays of the target compounds against two lung cancer cell lines, A549 and H460, a
The synthesis of 2-oxyalkyl-cyclohex-2-enones, related to the bioactive natural products COTC and antheminone A, which possess anti-tumour properties
Arthurs, Claire L.,Morris, Gareth A.,Piacenti, Michela,Pritchard, Robin G.,Stratford, Ian J.,Tatic, Tanja,Whitehead, Roger C.,Williams, Katharine F.,Wind, Natasha S.
experimental part, p. 9049 - 9060 (2011/01/04)
The syntheses of five novel 2-oxyalkyl-cyclohex-2-enones, structurally related to the natural products COTC and antheminone A, are described. The target structures were selected in order to probe the influence of several key structural parameters on in vi
