1024612-55-2

Upstream product

• 262590-66-9 Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine 
• 153290-53-0 (S)-3-(4-Benzyloxyphenyl)-2-(dibenzylamino)propan-1-ol 
• 262590-67-0 (S)-4-(4-Benzyloxy-phenyl)-3-dibenzylamino-butyronitrile 

Downstream Products

• 1024612-54-1 N,N-dibenzyl-β-L-homotyrosine methyl ester 
• 1024612-56-3 β³-L-homotyrosine methyl ester 

Relevant academic research and scientific papers

Treatment of N,N-dibenzylamino alcohols with sulfonyl chloride leads to rearranged beta-chloro amines, precursors to beta-amino acids, and not to tetrahydroisoquinolines.

[reaction: see text] Very recently, the unexpected formation of 3-substituted 1,2,3,4-tetrahydroisoquinolines starting from N,N-dibenzyl-protected beta-amino alcohols was reported. The authors claimed that treatment with tosyl chlorides induced intramolec