1024613-28-2Relevant academic research and scientific papers
Asymmetric synthesis of 4′-C-benzyl-2′,3′-dideoxynucleoside analogues from 3-benzyl-2-hydroxy-2-cyclopenten-1-one
Jogi, Artur,Ilves, Marit,Paju, Anne,Pehk, Tonis,Kailas, Tiiu,Mueuerisepp, Aleksander-Mati,Lopp, Margus
, p. 628 - 634 (2008/09/19)
Both enantiomers of the key intermediate, 2-benzyl-5-oxo-tetrahydro-furan-2-carboxylic acid were obtained by asymmetric oxidation of 3-benzyl-2-hydroxy-2-cyclopenten-1-one with an ee ≥96%, using the tartaric ester/Ti(OiPr)4/t-BuOOH complex, and transformed to the corresponding 4′-substituted nucleoside analogues with up to 61% overall yield.
