102469-74-9Relevant articles and documents
N-2-Aryl-1,2,3-Triazoles: A Novel Class of Blue Emitting Fluorophores-Synthesis, Photophysical Properties Study and DFT Computations
Padalkar, Vikas S.,Lanke, Sandip K.,Chemate, Santosh B.,Sekar, Nagaiyan
, p. 985 - 996 (2015)
Novel fluorescent 2-[4-(4,5-diphenyl-1H-imidazol-2-yl) phenyl]-2H-naphtho [1,2-d] [1,2,3] triazolyl derivatives were synthesized from 4-(4,5-diphenyl-1H-imidazol-2-yl) aniline and substituted naphthalen-2-amine. The photophysical properties of the three n
A novel “turn-on” fluorescence probe based on azoaniline-arylimidazole dyad for the detection of Cu2+
Wang, Yongpeng,Liu, Shuzhi,Chen, Hongbiao,Liu, Yijiang,Li, Huaming
, p. 293 - 299 (2017)
A novel fluorescence probe TPI-AD bearing azoaniline and arylimidazole moieties is conveniently synthesized for the detection of Cu2+. A “naked-eye” visible color change from colorless to lake-blue together with a 220-fold fluorescence enhancem
A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions
Kapale, Suraj S.,Chaudhari, Hemchandra K.,Mali, Suraj N.,Takale, Balaram S.,Pawar, Hitesh
, p. 712 - 716 (2021)
A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields. (Figure presented.).
Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum
Wicht, Kathryn J.,Combrinck, Jill M.,Smith, Peter J.,Hunter, Roger,Egan, Timothy J.
supporting information, p. 201 - 205 (2017/03/08)
In a previous study, target based screening was carried out for inhibitors of β-hematin (synthetic hemozoin) formation, and a series of triarylimidazoles were identified as active against Plasmodium falciparum. Here, we report the subsequent synthesis and testing of derivatives with varying substituents on the three phenyl rings for this series. The results indicated that a 2-hydroxy-1,3-dimethoxy substitution pattern on ring A is required for submicromolar parasite activity. In addition, cell-fractionation studies revealed uncommonly large, dose-dependent increases of P. falciparum intracellular exchangeable (free) heme, correlating with decreased parasite survival for β-hematin inhibiting derivatives.
Antinociceptive and antiinflammatory activities and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles
Puratchikody,Doble, Mukesh
, p. 1083 - 1090 (2007/10/03)
This paper describes the pharmacological evaluation pertaining to antinociceptive (hot plate and tail flick) and antiinflammatory (based on Carrageenan-induced paw oedema) activities, and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles. Compounds with phenyl substitution with -F, -Cl, -NH2, -N(CH3)2, -OH and -OCH3 at the p-position showed higher activity than the other substitutions in all the three studies. QSARs developed for the 60 and 120 s hot plate data indicate that the models for both the cases not only fit the data very well (R2 > 0.9, Radj2 > 0.86), but also have very good predictive capability (q2 > 0.81). The descriptors used in the model relate to surface area, volume, dipole moment and ADME properties of the molecule. Good QSARs for the 60 and 120 s tail flick data are developed. The models fit the data well (R2 > 0.8, Radj2 > 0.74), and in addition have good predictive capability (q2 > 0.66). Surface area, specifically polar surface area, HOMO and molecular connectivity index appear in the models. Very good QSAR model is developed for the antiinflammatory data (R2 = 0.86, Radj2 = 0.822 and q2 = 0.64) with aqueous solubility, number of hydrogen bond donor groups, surface area and principal moment of inertia as the molecular descriptors.
