102469-83-0

Basic information

• Product Name: 3-(4-methoxyphenyl)-4,5-diphenyl-4H-1,2,4-triazole
• Synonyms: 3-(4-methoxyphenyl)-4,5-diphenyl-4H-1,2,4-triazole
• CAS NO: 102469-83-0
• Molecular Weight: 327.385
• Mol File: 102469-83-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-4,5-diphenyl-4H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-4,5-diphenyl-4H-1,2,4-triazole(102469-83-0)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-4,5-diphenyl-4H-1,2,4-triazole(102469-83-0)

Safety Data

• Hazardous Substances Data: 102469-83-0(Hazardous Substances Data)

Upstream product

• 14331-64-7 3,4-diphenyl-1,2,4-triazole 
• 696-62-8 para-iodoanisole 

Relevant articles and documents

Br?nsted acid-catalyzed simple and efficient synthesis of 1,2,4-triazoles and 1,2,4-oxadiazoles using 2,2,2-trichloroethyl imidates in PEG

A facile and highly efficient synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and 3,5-disubstituted 1,2,4-oxadiazoles from 2,2,2-trichloroethyl imidates using PEG as a solvent and employing PTSA as the catalyst under mild conditions is described.

Method for synthesizing aryl-substituted triazole compound

The invention provides a method for synthesizing an aryl-substituted 1,2-4-triazole compound of formula (I) as shown in the specification. The method comprises the following steps: in an organic solvent, in the presence of an organic copper catalyst, an alkali and a solubilizer, enabling a compound of formula (II) as shown in the specification and a compound of formula (III) as shown in the specification to react in an inert atmosphere, so as to obtain the compound formula (I) as shown in the specification, in the formula, R1, R2 and R3 are respectively and independently H, C1-C6 alkyl, C1-C6alkoxy, halogen or nitryl, and X is halogen. By adopting the method, through appropriate selection/combination of catalysts, alkalis, solubilizers and organic solvents, a target product of high yieldis prepared, and the method has wide application prospects and great industrial values in the field of synthesis of medicine intermediates.

Ligand-free copper(0) catalyzed direct C-H arylation of 1,2,4-triazoles and 1,3,4-oxadiazoles with aryl iodides in PEG-400

A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction medium. The procedure is experimentally simple and free from addition of external chelating ligands or co-catalysts.

Copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides

The copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides proceeds efficiently in the presence of suitable ligands and bases. This method allows the installation of a variety of aryl moieties bearing a functional group such as ketone, ester, or nitrile so as to enable the facile construction of various functionalized oxadiazole and triazole core π systems.