1024916-48-0Relevant academic research and scientific papers
Michael addition of ortho-lithiated aryloxiranes to α,β- unsaturated malonates: Synthesis of tetrahydroindenofuranones
Salomone, Antonio,Capriati, Vito,Florio, Saverio,Luisi, Renzo
, p. 1947 - 1950 (2008)
A short and efficient synthesis of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described. The methodology has been applied to the synthesis of a structural analogue of epipodophyllotoxins.
