1025-49-6Relevant academic research and scientific papers
Benzobutyrolactone derivatives, synthetic method and application thereof in preparation of bactericides
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Paragraph 0049; 0050; 0051; 0056, (2018/04/03)
The invention discloses benzobutyrolactone derivatives, a synthetic method and application thereof in preparation of bactericides. The method comprises the following steps: taking sesquiterpene lactone pharmacophore alpha-methylene-gamma-butyrolactone as a lead compound, integrating benzofuranone pharmacophore, modifying at an alpha-methylene position, and performing directional derivative synthesis to obtain a series of alpha-alkenylene benzobutyrolactone compounds. The antibacterial activities of the compounds are determined, and two high-activity compounds with excellent industrialization development prospects are synthesized on the structure-effect basis. The compounds are used for controlling plant diseases caused by pathogenic bacteria such as wheat powdery mildew, wheat scab, take-all disease of wheat, wheat sharp eyespot, corn northern leaf blight, rice sheath blight disease, rice blast, cotton damping-off, phytoph-thora capsici leonian, botrytis cinerea, tomato leaf mould, tomato early/late blight, cucumber anthracnose, fusarium wilt of cucumber, sclerotinia rot of colza and the like.
