1025-50-9Relevant academic research and scientific papers
Sodium Butylated Hydroxytoluene: A Functional Group Tolerant, Eco-Friendly Base for Solvent-Free, Pd-Catalysed Amination
Semeniuchenko, Volodymyr,Braje, Wilfried M.,Organ, Michael G.
supporting information, p. 12535 - 12539 (2021/08/03)
NaBHT (sodium 2,6-di-tert-butyl-4-methylphenolate), a strong, but hindered and lipophilic base, has been effectively paired with similarly lipophilic, high-reactivity Pd-NHC (N-heterocyclic carbene) catalysts to produce an ideal combination for performing
Nickel-Catalyzed Photoredox-Mediated Cross-Coupling of Aryl Electrophiles and Aryl Azides
Konev, Mikhail O.,McTeague, T. Andrew,Johannes, Jeffrey W.
, p. 9120 - 9124 (2018/09/25)
Medicinally relevant diarylamines are prepared through a photoredox-mediated dual catalytic nickel/ruthenium system from aryl azides and aryl electrophiles. Photoreduction of the aryl azide is proposed to proceed through an arylnickel-azide complex, which upon reduction and loss of nitrogen, generates a nickel(III) species capable of facile reductive elimination to afford the desired C-N bond formation. A variety of functionalized (hetero)aryl electrophiles are shown to participate in the coupling, including iodides, bromides, chlorides, and triflates. The reactions are simple to set up and are performed under ambient conditions, without the exclusion of oxygen or moisture.
Method for synthesizing diarylamine by optical/nickel concerted catalysis
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Paragraph 0046; 0047; 0048; 0049; 0128; 0129; 0130; 0131, (2018/09/08)
The invention discloses a method for synthesizing diarylamine by optical/nickel concerted catalysis. According to the method, a ligand does not need to be added, and simple and cheap nickel salt is directly used as a metal catalyst to cooperate with a photosensitizer to catalyze arylamine and aryl bromide to generate cross-coupling. The method has the following advantages: (1) the use amount of BODIPY type organic photocatalyst is low, and the BODIPY type organic photocatalyst has a better catalysis effect in comparison with metal iridium and ruthenium photocatalysts reported in the literature; (2) the BODIPY type organic photocatalyst is easy for synthesis; (3) the use amount of nickel salt is few, and the ligand does not need to be added; and (4) the reaction conditions are mild, and theyield of most coupling products is higher than 90%. According to the method disclosed by the invention, high temperature and high pressure equipment is not needed, temperature change scope is small,experimental procedure is simple and easy to operate, and the method has a relatively high application value and industrial popularization potential.
Method for synthesis of quinoline-8-amine and derivatives thereof from fluoroquinolines
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Page/Page column 5; 11, (2018/02/28)
The invention discloses a method for synthesis of quinoline-8-amine and derivatives thereof from fluoroquinolines, and belongs to the technical field of organic synthesis. The quinoline-8-amine and the derivatives thereof are prepared from fluoroquinoline compounds and aromatic amines compounds as a substrate in the presence of solvent toluene and hydrides by synthesizing reaction. The method is simple in operation and suitable for industrial production. The raw materials needed for the synthesis are cheap, the cost of the synthesis is low, and a variety of amino quinoline derivatives can be synthesized by the simple and single method.
Transition-metal-free site-selective C–F bond activation for synthesis of 8-aminoquinolines
Chen, Jianping,Huang, Dongyang,Ding, Yuqiang
, p. 4240 - 4242 (2017/10/10)
An efficient and general selective method for the synthesis of 8-aminoquinoline derivatives has been disclosed through transition metal direct C–N coupling from fluoroquinolines and arylamines. Significantly, good chemo- and regio-selectivity was observed
