10250-59-6

Basic information

• Product Name: 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER
• Synonyms: 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER;1H-Pyrazole-5-carboxylic acid, 1,3-diMethyl-, Methyl ester;Methyl 1,3-diMethyl-1H-pyrazole-5-carboxylate;1,3-Dimethyl-1H-pyrazole-5-carboxylic acid methyl ester;Methyl 2,5-dimethyl-2H-pyrazole-3-carboxylate;2,5-dimethyl-2H-pyrazole-3-carboxylic acid methyl ester;1,3-diMethyl-, Methyl ester;Methyl 1,3-Dimethyl-1H-Pyrazole-5-Carboxylate(WXC00828)
• CAS NO: 10250-59-6
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.1665
• Mol File: 10250-59-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 242.0±20.0 °C(Predicted)
• Flash Point: 78℃
• Appearance: /
• Density: 1.150 g/mL at 25 °C
• Refractive Index: n20/D1.491
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.94±0.10(Predicted)
• CAS DataBase Reference: 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER(10250-59-6)
• EPA Substance Registry System: 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER(10250-59-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: NA 1993 / PGIII
• WGK Germany: 1
• Hazardous Substances Data: 10250-59-6(Hazardous Substances Data)

Usage

Uses

Methyl 1,3-Dimethyl-1H-pyrazole-5-carboxylate is used as a reactant in the preparation of pyrazolyl acrylonitrile derivatives as acaricides.

Upstream product

• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 74-88-4 methyl iodide 
• 25016-17-5 3-methyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 553-90-2 Dimethyl oxalate 
• 67-64-1 acetone 
• 77-78-1 dimethyl sulfate 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 

Downstream Products

• 5744-56-9 1,3-dimethylpyrazol-5-carboxylic acid 
• 773136-70-2 methyl 1,3,4-trimethylpyrazole-5-carboxylate 
• 1454848-24-8 ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamic acid tert-butyl ester 
• 1454846-35-5 (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 
• 1182280-64-3 N-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-4-(5-trifluormethyl-pyridin-2-yloxy)-benzenesulfonamide 
• 499770-63-7 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine 
• 25016-09-5 1,3-dimethyl-1H-pyrazole-5-carbaldehyde 
• 57012-20-1 (1,3-dimethyl-1H-pyrazol-5-yl)methanol 

Relevant articles and documents

Benzoxadiazepine tetradecene derivative and application thereof

The invention discloses a benzoxadiazepine tetradecene derivative and application thereof, belonging to the field of medicines. The benzoxadiazepine tetradecene derivative with a structure as shown ina general formula (I) has excellent anaplastic lymphoma enzyme (ALK) inhibition activity and excellent pharmacodynamic performance, and can obviously prolong the large metabolic half-life period of adrug; the derivative can be safely and effectively used for treating anaplastic lymphoma kinase positive (ALK+) metastatic (advanced) non-small cell lung cancer (NSCLC) and the like, thereby providing a new means for treating cancers, metabolic and immune diseases, cardiovascular diseases, neurological diseases and the like.

Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

A series of novel pyrazolyl acrylonitrile derivatives was designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of1H NMR,13C NMR, and MS spectra. The structures of compounds 18 and 19 were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound 19 exhibits excellent acaricidal activity against all developmental stages of T. cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds 19 to mammals is quite low. The structure-activity relationships are also discussed.

METHODS FOR PREPARING INDAZOLE COMPOUNDS

The invention relates to methods for preparing compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) are useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.