102516-93-8

Basic information

• Product Name: 5,6-dichloro-2-(pentafluoroethyl)-1H-benzimidazole
• Synonyms: 1H-benzimidazole, 5,6-dichloro-2-(1,1,2,2,2-pentafluoroethyl)-; 1H-Benzimidazole, 5,6-dichloro-2-(pentafluoroethyl)-
• CAS NO: 102516-93-8
• Molecular Formula: C₉H₃Cl₂F₅N₂
• Molecular Weight: 305.0315
• Mol File: 102516-93-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 340.1°C at 760 mmHg
• Flash Point: 159.5°C
• Density: 1.695g/cm³
• Vapor Pressure: 0.000173mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 5,6-dichloro-2-(pentafluoroethyl)-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dichloro-2-(pentafluoroethyl)-1H-benzimidazole(102516-93-8)
• EPA Substance Registry System: 5,6-dichloro-2-(pentafluoroethyl)-1H-benzimidazole(102516-93-8)

Safety Data

• Hazardous Substances Data: 102516-93-8(Hazardous Substances Data)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 422-64-0 pentafluoropropionic acid 

Relevant articles and documents

Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles

The synthesis of several halogenated benzimidazoles substituted in position 2 with trifluoromethyl, pentafluoroethyl and 2-thioethylaminodimethyl group is reported. Antiprotozoal and anticancer activity of series of newly synthesized and previously obtained compounds was studied. All of tested bezimidazoles showed remarkable antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Of the studied collection of halogenated benzimidazoles the most anticancer-active was the 5,6-dichloro-2-pentafluoroethyl compound, particularly against breast and prostate cancer cell lines.

NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)

The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.