1025294-19-2Relevant articles and documents
Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: New structural insight into the HIV-1 integrase inhibition
Vandurm, Pierre,Guiguen, Allan,Cauvin, Christine,Georges, Beno?t,Le Van, Kiet,Michaux, Catherine,Cardona, Christelle,Mbemba, Gladys,Mouscadet, Jean-Franois,László Hevesi,Van Lint, Carine,Wouters, Johan
experimental part, p. 1749 - 1756 (2011/05/06)
New quinolonyl diketo acid compounds bearing various substituents at position 6 of the quinolone scaffold were designed and synthesized as potential HIV-1 integrase inhibitors. These new compounds were evaluated for their antiviral and anti-integrase acti