102532-71-8Relevant articles and documents
Copper(I) complexes with bidentate tertiary phosphine ligands: Solution chemistry and antitumor activity
Berners-Price, Susan J.,Johnson, Randall K.,Mirabelli, Christopher K.,Faucette, Leo F.,McCabe, Francis L.,Sadler, Peter J.
, p. 3383 - 3387 (2008/10/08)
Copper may play an important role in the antitumor activity of diphosphines. The tetrahedral bischelated copper(I) complexes [Cu(dppey)2]Cl and [Cu(dppp)2]Cl, where dppey is Ph2PCH=CHPPh2 and dppp is Ph2P(CH2)3PPh2, were synthesized and characterized. The bridged dicopper(I) complex (CuCl)2(dppe)3, where dppe is Ph2P(CH2)2PPh2, underwent dissociative equilibria in CDCl3 and CD2Cl2 solutions, as determined by temperature-dependent 1H and 31P NMR studies. One of the products was [Cu(dppe)2]+, the proportion of which increased on adding excess dppe. The complex was also a product from the reaction of Cu2+ with excess dppe in DMA. The complexes [Cu(P-P)2]Cl, where P-P is dppey or dppp, and (CuCl)2(dppe)3 were all active against P388 leukemia, M5076 reticulum cell sarcoma, and B16 melanoma. [Cu(eppe)2]Cl, where eppe is Et2P(CH2)2PPh2, was active only against P388 leukemia. The activities were comparable to those of the analogous Au(I) complexes, and complexes were more potent than the free ligands.
