102536-31-2

Upstream product

• 110-70-3 N,N`-dimethylethylenediamine 
• 102536-27-6 2,3-dihydro-6-(3-hydroxyphenyl)-1,4-diazepinium perchlorate 
• 74-88-4 methyl iodide 

Downstream Products

• 102588-12-5 2,3-dihydro-6-(3-methoxyphenyl)-1,4-dimethyl-1,4-diazepinium perchlorate 
• 102536-37-8 6-(2,4-dibromo-5-hydroxyphenyl)-2,3-dihydro-1,4-dimethyl-1,4-diazepinium perchlorate 
• 102536-33-4 6-(4-bromo-3-hydroxyphenyl)-2,3-dihydro-1,4-dimethyl-1,4-diazepinium perchlorate 

Relevant academic research and scientific papers

Alkylation of 2,3-Dihydro-1,4-diazepinium Salts

N-Unsubstituted 2,3-dihydro-1,4-diazepinium salts 4a-d are N-methylated readily (--> 5a-d) by using iodomethane and potassium carbonate in dimethylformamide.The 2,3-dihydro-5,7-diphenyl-1,4-diazepinium salt 4d could be N-ethylated but not N-isopropylated, presumably for steric reasons.Vicinal crowding between 1,4-alkyl and 5,7-phenyl substituents at the dihydrodiazepinium ring is evident from NMR spectra. 2,3-Dihydro-6-(hydroxyphenyl)-1,4-diazepinium salts (2a,b) are methylated first at the nitrogen atoms (--> 1a, b) and only then at the hydroxy group (--> 3a, b).

Experiments towards the Preparation of 6-Hydroxy-, 6-Methoxy-, and 6-(Hydroxyphenyl)-2,3-dihydro-1,4-diazepinium Salts and 1,2-Dihydro-5-(hydroxyphenyl)-2-oxopyrimidinium Salts

The preparation of a number of 2,3-dihydro-6-(hydroxyphenyl)-1,4-diazepinium salts (11c-f) and of 1,2-dihydro-5-(hydroxyphenyl)-2-oxopyrimidinium salts (17a, b) from 3-(hydroxyphenyl)vinamidinium salts (10b,c) is described.Attempted preparation of a 3-(2-