1025389-25-6Relevant articles and documents
Total synthesis of (±)-murrayazoline
Ueno, Akiko,Kitawaki, Takafumi,Chida, Noritaka
supporting information; experimental part, p. 1999 - 2002 (2009/04/10)
The total synthesis of (±)-murrayazoline (1) is described. The characteristic hexa-heterocyclic structure of 1 was constructed by a combination of the intramolecular Friedel-Crafts-type Michael addition and Pd-catalyzed C-O coupling reactions. The N-substituted carbazole component was synthesized in one pot by the double N-arylation of a sterically hindered amine with a dibromobiphenyl derivative.