10254-89-4

Basic information

• Product Name: 4-(morpholinosulfonyl)benzonitrile
• Synonyms: 4-(morpholinosulfonyl)benzonitrile;p-(Morpholinosulfonyl)benzonitrile;Benzonitrile, 4-(4-morpholinylsulfonyl)-
• CAS NO: 10254-89-4
• Molecular Formula: C₁₁H₁₂N₂O₃S
• Molecular Weight: 252.28958
• Mol File: 10254-89-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(morpholinosulfonyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(morpholinosulfonyl)benzonitrile(10254-89-4)
• EPA Substance Registry System: 4-(morpholinosulfonyl)benzonitrile(10254-89-4)

Safety Data

• Hazardous Substances Data: 10254-89-4(Hazardous Substances Data)

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 110-91-8 morpholine 
• 1828-66-6 morpholine-4-sulfonyl chloride 
• 126747-14-6 4-cyanophenylboronic acid 
• 852399-79-2 [4-(morpholine-4-sulfonyl)phenyl]methanamine 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 

Downstream Products

• 1453173-69-7 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(morpholine-4-sulfonyl)-benzylamide 
• 1450723-44-0 N-[(4-morpholinosulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450724-24-9 4-nitrophenyl N-[[4-(morpholine-4-sulfonyl)phenyl]methyl]carbamate 
• 852399-79-2 [4-(morpholine-4-sulfonyl)phenyl]methanamine 

Relevant articles and documents

One-Pot Sulfonamide Synthesis Exploiting the Palladium-Catalyzed Sulfination of Aryl Iodides

Aryl ammonium sulfinates, conveniently prepared from aryl iodides and the sulfur dioxide surrogate DABSO, under the action of a palladium(0) catalyst, are transformed in a one-pot process to a variety of functionalized sulfonamides. The sulfinate to sulfonamide transformation is achieved by simple treatment with an aqueous solution of the relevant amine and sodium hypochlorite (bleach). A broad range of amines, including anilines, and amino acid derivatives, are combined efficiently with a variety of aryl iodides, leading to sulfonamides in high yields.

ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the N- oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, formula (I) wherein A, R1, R2, R3, R3', R4, R4', X, Y, Z, T are as defined in the claims. The invention further relates to an in vitro method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, inflammatory disorders, cardiovascular diseases, viral induced diseases, circulatory diseases, fibro-proliferative diseases and pain sensitization disorders.

"Nanorust"-catalyzed benign oxidation of amines for selective synthesis of nitriles

Organic nitriles constitute key precursors and central intermediates in organic synthesis. In addition, nitriles represent a versatile motif found in numerous medicinally and biologically important compounds. Generally, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. Herein, we report the selective and environmentally benign oxidative conversion of primary amines for the synthesis of structurally diverse aromatic, aliphatic and heterocyclic nitriles using a reusable "nanorust" (nanoscale Fe2O3)-based catalysts applying molecular oxygen.