1025403-20-6Relevant articles and documents
Design and application of hybrid phosphorus ligands for enantioselective Rh-Catalyzed anti-markovnikov hydroformylation of unfunctionalized 1,1-disubstituted Alkenes
You, Cai,Li, Shuailong,Li, Xiuxiu,Lan, Jialing,Yang, Yuhong,Chung, Lung Wa,Lv, Hui,Zhang, Xumu
supporting information, p. 4977 - 4981 (2018/04/24)
A series of novel hybrid phosphorus ligands were designed and applied to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes. By employing the new catalyst, linear aldehydes with β-chirality can be prepared with high yields and enantioselectivities under mild conditions. Furthermore, catalyst loading as low as 0.05 mol % furnished the desired product in good yield and undiminished selectivity, demonstrating the efficiency of this transformation in large-scale synthesis.
Asymmetric transfer hydrogenation in aqueous media catalyzed by resin-supported peptide having a polyleucine tether
Akagawa, Kengo,Akabane, Hajime,Sakamoto, Seiji,Kudo, Kazuaki
scheme or table, p. 461 - 466 (2009/09/06)
A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for both reaction efficiency and enantioselectivity.
Organocatalytic asymmetric transfer hydrogenation in aqueous media using resin-supported peptide having a polyleucine tether
Akagawa, Kengo,Akabane, Hajime,Sakamoto, Seiji,Kudo, Kazuaki
supporting information; experimental part, p. 2035 - 2037 (2009/04/18)
A resin-supported N-terminal prolyl peptide having a β-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.
Total synthesis of sporochnols, fish deterrents from a marine alga
Ohira, Susumu,Kuboki, Atsuhito,Hasegawa, Taisuke,Kikuchi, Takato,Kutsukake, Tatsuhiko,Nomura, Maki
, p. 4641 - 4644 (2007/10/03)
Sporochnols, fish deterrents from a marine alga, were synthesized, using intramolecular C-H insertion of alkylidenecarbene as a key step to construct the chiral quaternary center.
